The variations may not be significant among some producers, but the slightest difference can determine how well the shoe fits you. Once you do find a shoe that just seems perfect for you, probably that will not change unless you gain weight, etc.
Running is a great help for our cardiovascular system and provides peace of mind. Despite of the benefits it offers, it commonly hurts the feet of the runner due to the long run. The best way to prevent the feet of the runner from being hurt, using a pair of running shoes can protect. This will help the runner to lift his experience to a safe run.